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Session 1:
Thiazolidinediones (TZDs)
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What are the relative merits/disadvantages of pioglitazone and rosiglitazone, two TZD drugs?
At what ejection fraction value would you not use pioglitazone for fear of exacerbating congestive heart failure?
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Session 2:
Incretins
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What are the pros and cons of injectable incretins and orally available DPP-4 inhibitors?
My patients tend to gain weight with insulin and SU drugs. Is this side effect observed with DPP-4 inhibitors and incretins?
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Session 3:
Side Effects
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Exenatide frequently causes nausea in my patients; what strategies can help manage this side effect?
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Session 4:
Exenatide Safety & Emerging Agents
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Pancreatitis has been reported in patients treated with exenatide. Is this AE drug-related, and is it observed with sitagliptin?
There are other DPP-4 inhibitors in clinical development. What are the distinguishing features of the emerging drugs?
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Session 5:
Combinations of Drugs
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The ADA consensus panel preferred metformin as the front line agent. What is the best strategy for adding insulin, TZDs, incretins, DPP-4 inhibitors or SUs to metformin?
What are the special considerations for obesity, renal impairment, liver disease, or other comorbidities?
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Session 6:
Cost Considerations
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Cost of medications is a key factor for chronic diseases such as diabetes. Isn't the combination of metformin + pioglitazone + incretin mimetic/DDP-4 much more expensive than using metformin and insulin?
Are the clinical advantages of incretins and DPP-4 inhibitors worth the price difference?
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